Volga Bulmuş

volga

Lab Website: bulmusgroup.iyte.edu.tr
Email: volgabulmus@iyte.edu.tr
Office: Science Faculty Building, Block A, Office No 214/A
Phone: (232) 750-7381
Courses: BENG506 – Biomaterials
BTEC598 – Research Seminar
CHE211 – Introduction to Polymer Science

Volga Bulmuş, PhD

Professor, Department of Bioengineering


Research-at-a-glance:

  • Nanomedicine
  • Polymer Therapeutics
  • Drug/gene delivery systems: targeted systems, intracellular drug delivery, gene silencing.
  • Polymer Chemistry
  • Functional Polymers
  • Polymer-inorganic interface engineering for drug delivery and biosensors

Biography:

Prof. Bulmus attended Hacettepe University for her undergraduate and graduate degrees. She obtained her B.S. in Chemical Engineering in 1993 and her PhD in Bioengineering in 2000, developing a new method utilizing temperature-responsive polymers for soluble phase peptide synthesis under the supervision of Prof. Erhan Pişkin.

Between 2001 and 2003, she worked as a postdoctoral research fellow in Prof. Allan S. Hoffman and Prof. Patrick Stayton joint research group at Department of Bioengineering, University of Washington, Seattle, WA, USA. During her studies in Hoffman-Stayton Labs, she was involved in projects aiming to develop pH-responsive membrane-disruptive polymers for intracellular delivery of antisense therapeutics.

In 2004, she joined Centre for Advanced Macromolecular Design (CAMD) at the University of New South Wales (UNSW), Sydney, NSW, Australia, as a Vice Chancellor’s Research Fellow. At CAMD, in collaboration with Prof. Thomas P. Davis, she used reversible addition-fragmentation chain transfer (RAFT) polymerization to generate well-defined polymers for bioconjugations and drug delivery applications. In 2008, she was appointed as a tenured faculty member by the School of Biotechnology and Biomolecular Sciences (BABS) at UNSW where she established a research laboratory working on generation of polymeric nanomedicines via RAFT polymerization.

In 2010, she joined, as an Associate Professor, Department of Chemical Engineering at Izmir Institute of Technology (Iztech), Izmir, Turkey. She was then promoted to Professor of Chemical Engineering in 2013 and Professor of Bioengineering in 2015. She is the founding chair of Department of Bioengineering at IzTech.

Prof. Bulmus currently leads a group of 5-10 researchers working on development of advanced polymeric systems for biotechnology and biomedicine applications ranging from nanomedicines for anticancer chemotherapy and gene silencing therapies to biopurifications. Bulmus Research Group generally uses RAFT polymerization to synthesize well-defined polymers with controlled molecular weight, narrow molecular weight distribution, desired end-group functionality and molecular architecture. Specifically, Prof. Bulmus and coworkers have developed and biologically evaluated new, well-defined, pH-responsive, biosynthetic hybrid polymeric systems including soluble polymers, micelles and organic/inorganic nanoparticles for (targeted) intracellular delivery of drugs and genes. The team has also developed biomolecule (protein/RNA) – polymer conjugates for potential biopurifications and nanomedicine applications. Additionally, they have developed biosensor chips using end-group functionalized stimuli-responsive polymers and metal surfaces.

Prof. Bulmus and coworkers have published over 75 peer-reviewed articles, receiving more than 4000 citations and contributed presentations at various international workshops and conferences.

Research Areas:

  • Nanomedicine
  • Drug Delivery
  • Macromolecular Engineering
  • Biomaterials

Selected Publications:

Uz, M.; Bulmus, V.; Altınkaya, S.A., Effect of PEG Grafting Density and Hydrodynamic Volume on Gold Nanoparticle-Cell Interactions: An Investigation on Cell Cycle, Apoptosis, and DNA Damage, Langmuir, 32 (23), 5997-6009, 2016.

Kurtulus, I.; Yilmaz, G.; Ucuncu, M.; Emrullahoglu, M.; Becer, R.; Bulmus, V.*, A new proton sponge polymer synthesized by RAFT polymerization for intracellular delivery of biotherapeutics, Polymer Chemistry, 5, 1593-1604, 2014. (BACK COVER PAGE ARTICLE)

Sevimli, S.; Inci, F.; Zareie, H.; Bulmus, V.*, Well-Defined Cholesterol Polymers with pH-Controlled Membrane Switching Activity, Biomacromolecules, 13 (10), 3064-3075, 2012.

Boyer, C., Bulmus, V., Davis, T.P., Ladmiral, V., Liu, J., Perrier, S., Bioapplications of RAFT polymers, Chemical Reviews, 109 (11), 5402-5436, 2009.

Jia, Z., Wong, L-J., Davis, T.P., Bulmus V.*, One-Pot Conversion of HPMA Copolymers to Acid- and Reductant-Sensitive Crosslinked Micelles via RAFT Polymerization, Biomacromolecules, 9 (11), 3106-3113, 2008.

Heredia, K. L., Nguyen, T. H., Chang, C-W., Bulmus, V.*, Davis, T. P., and Maynard H.D., Reversible siRNA-Polymer Conjugates by RAFT Polymerization, Chemical Communications, 28, 3245-3247, 2008. (COVER PAGE ARTICLE AND HOT ARTICLE)

Chan, Y., Wong, T., Byrne, F., Kavallaris, M., Bulmus, V.*, Acid-Labile Core Cross-linked Micelles for pH-Triggered Release of Antitumor Drugs, Biomacromolecules, 9 (7), 1826-1836, 2008.

Zareie, H.M., Boyer, C., Bulmus, V.*, Nateghi, E., Davis, T.P., Temperature-responsive self-assembled monolayers of oligo(ethylene glycol): Control of biomolecular recognition, ACS Nano, 2 (4), 757-765 2008.

Boyer, C., Bulmus, V.*, Liu, J., Davis, T.P., Stenzel, M.H., Barner-Kowollik C., Well-Defined Protein-Polymer Conjugates via RAFT Polymerization, Journal of The American Chemical Society, 129, 7145-7154, 2007.

Liu, J., Bulmus, V.*, Herlambang, D., Barner-Kowollik, C., Stenzel, M.H., Davis, T.P., In-Situ Formation of Protein-Polymer Conjugates via Reversible Addition Fragmentation Chain Transfer Polymerization, Angewandte Chemie International Edition, 46, 3099-3103, 2007.